Luísa Penha was born in the city of Porto in 1958. She attended the Architecture course at ESBAP in her hometown. In 1986, she graduated from F.AU.P with a grade of 16 out of 20, and was awarded the Eng. António de Almeida Prize for having the highest grade of the academic year (85/86).
Since 1978, she has been collaborating with the architect Siza Viera, and has been practicing independently since 1984.